Dr. Harry Wolper is an eccentric medical professor teaching at a small southern California college who is obsessed with making a clone of his wife Lucy who died in childbirth 30 years earlier. Harry hires Boris Lafkin, a struggling pre-med student as his personal assistant to help him with his experiments by obtaining lab equipment and working in his backyard shed in exchange for which Harry gives Boris love life advice in courting an attractive coed named Barbara who slowly becomes smitten with Boris. To continue his research into cloning, Harry meets and employes a young woman, named Meli, who practically moves in with him on an agreement to contribute her ovary sample as part of the cloning progress. Meli slowly falls for the much older Harry who begins to question his ethics and vision of true love. Meanwhile, a rival of Harry's, fellow medical professor Dr. Sid Kuhlenbeck, tries to investigate and hinder Harry's cloning plans as part of a ploy to remove Harry from the university to take over Harry's lab for himself.
When the band first formed, Deily and Dando would swap instruments, playing guitar and singing on tracks each wrote himself, and drums for songs the other wrote. The first "official" Lemonheads drummer, Doug Trachten, was brought in for their first album Hate Your Friends. On Creator, John Strohm of the band Blake Babies plays drums on all of the original tracks, while Mark Natola played drums for the two live bonus songs at the end of the CD reissue. Also, by the time the live tracks were recorded—during the European tour supporting the Lemonheads' final TAANG! album, Lick (1989)—Deily had left the band to complete his degree at Harvard College; lead guitar on those tracks (and the voice of "Evan Dando" during the interview segment) is provided by Corey Loog Brennan.